| Steel Horizon (Europe) (En,Fr,De,Es,It) | |
| Steel Horizon (USA) | |
| Sternentaenzer - Das Geheimnisvolle Pferd (Europe) (En,De) | |
| Steve Soresi no Business Eikaiwa Pera Pera DS Training (Japan) | |
| Steve Soresi no Eikaiwa Pera Pera DS Training (Japan) | |
| Stitch Jam (USA) | |
| Stitch! DS - Ohana to Rhythm de Daibouken (Japan) | |
| Stratego - Next Edition (Europe) (En,Fr,De,Es,Nl) | |
| Strawberry Shortcake - Strawberryland Games (Europe) (En,Fr,De,Es,Nl,No) | |
| Strawberry Shortcake - Strawberryland Games (USA) (En,Fr,Es) | |
| Strawberry Shortcake - The Four Seasons Cake (Europe) (En,Fr,De,Es,It,Nl) | |
| Strawberry Shortcake - The Four Seasons Cake (USA) (En,Fr,Es) | |
| Street Football (Europe) (En,Fr,De,Es,It) | |
| Strike Witches - Soukuu no Dengekisen - Shin Taichou Funtou Suru! (Japan) | |
| Strike Witches 2 - Iyasu, Naosu, Punipuni Suru (Japan) | |
| Style Book - Cinnamoroll (Japan) | |
| Style Book - Fushigi Boshi no Futago Hime Gyu! (Japan) | |
| Style Book - Junior City (Japan) | |
| Style Lab - Jewelry Design (USA) (En,Fr,Es) (NDSi Enhanced) | |
| Style Savvy (USA) | |
| Subarashiki Kono Sekai - It's a Wonderful World (Japan) (Rev 1) | |
| Subbuteo (Europe) (En,Fr,De,Es,It) | |
| Successfully Learning Mathematics (Europe) (En,Fr,De,Es,It,Ru) | |
| Sudoku Ball Detective (Europe) (En,Fr,De,Es,It,Nl) | |
| Sudoku Ball Detective (USA) (En,Fr,Es) | |
| Sudoku DS - Nikoli no 'Sudoku' Ketteiban (Japan) | |
| Sudoku DS (Korea) | |
| Sudoku Gridmaster (USA) | |
| Sudoku Mania - Enhance Your Critical Thinking Skills! (USA) | |
| Sudoku Master (Europe) (En,Fr,De,Es,It,Nl) | |
| Sudokumaniacs (Europe) (En,De,Es,It) | |
| Sudokumaniacs (France) | |
| Sudokuro - Sudoku & Kakuro Games (USA) | |
| Sudokuro (Europe) (En,Fr,De,Es,It) | |
| Sueddeutsche Zeitung Wissen Mehr Kreuzwortraetsel (Germany) | |
| Sugar Bunnies DS - Yume no Sweets Koubou (Japan) (Rev 1) | |
| Sugar Sugar Rune - Queen Shiken wa Dai-panic (Japan) | |
| Suikoden - Tierkreis (Europe) (En,Fr,De,Es,It) | |
| Suikoden - Tierkreis (USA) (En,Fr,Es) | |
| Suite Life of Zack & Cody, The - Circle of Spies (Europe) (En,Fr,De,Es,It,Nl) | |
| Suite Life of Zack & Cody, The - Circle of Spies (USA) (En,Fr,De,Es,It,Nl) | |
| Suite Life of Zack & Cody, The - Tipton Trouble (USA) (En,Fr) | |
| Sukashikashipanman DS - 'Shokotan' Koto Nakagawa Shoko Produce (Japan) | |
| Suki Desu Suzuki-kun!! - 4-nin no Suzuki-kun (Japan) | |
| Sumeoinneun Nunui Him - DS Allyeok Training (Korea) | |
| Sumeun Sojireul Kkaeuneun - Geurimgyosil (Korea) (NDSi Enhanced) | |
| Summon Night - Twin Age (USA) | |
| Summon Night (Japan) | |
| Summon Night 2 (Japan) | |
| Summon Night Twin Age - Seirei-tachi no Koe (Japan) | |