| Shamu's Deep Sea Adventures (Europe) | |
| Shamu's Deep Sea Adventures (USA) | |
| Shane Watson's Power Play Cricket 2011 (Australia) | |
| Shanghai (Japan) | |
| Shaun the Sheep - Off His Head (Europe) (En,Fr,De,Es,It) | |
| Shaun the Sheep (Europe) (En,Ja,Fr,De,Es,It) | |
| Shaun the Sheep (USA) (En,Ja,Fr,De,Es,It) | |
| Shaun White Snowboarding (Europe) (En,Fr,De,Es,It) | |
| Shaun White Snowboarding (USA) (En,Fr,Es) | |
| Shawn Johnson Gymnastics (USA) (En,Fr,Es) | |
| Shepherd's Crossing 2 DS (USA) | |
| Sherlock Holmes - The Mystery of the Mummy (USA) (En,Fr,Es) | |
| Sherlock Holmes DS - The Mystery of the Mummy (Europe) (En,Fr,De,Es,It) | |
| Sherlock Holmes DS and the Mystery of Osborne House (Europe) (En,Fr,De,Es,It,Nl) | |
| Shibou Nenshou Keikaku - Yasetore!! DS (Japan) | |
| Shichida Shiki Training - Unou Tanren Unotan DS - Shun Kan Shoubu! Handanryoku (Japan) | |
| Shichida Shiki Training - Unou Tanren Unotan DS - Shun Kan Shoubu! Kiokuryoku (Japan) | |
| Shichida Shiki Training - Unou Tanren Unotan DS - Shun Kan Shoubu! Shuuchuuryoku (Japan) | |
| Shichidasik Unoedallyeon - Super Brain (Korea) | |
| Shikaku Kentei DS (Japan) | |
| Shikakui Atama o Maruku Suru. DS - Joushiki, Nanmon no Shou (Japan) | |
| Shikakui Atama o Maruku Suru. DS - Kanji no Shou (Japan) | |
| Shikakui Atama o Maruku Suru. DS - Keisan no Shou (Japan) | |
| Shin chan - Aventuras de Cine! (Spain) | |
| Shin chan contra los Plastas! (Spain) | |
| Shin chan e i Colori Magici! (Italy) | |
| Shin chan Flipa en Colores! (Spain) | |
| Shin Lucky Star Moe Drill - Tabidachi (Japan) | |
| Shin Megami Tensei - Devil Survivor (USA) | |
| Shin Megami Tensei - Devil Survivor 2 (USA) | |
| Shin Megami Tensei - Strange Journey (Japan) | |
| Shin Megami Tensei - Strange Journey (USA) | |
| Shin Sangoku Musou DS - Fighter's Battle (Japan) | |
| Shin Sengoku Tenka Touitsu - Gunyuu-tachi no Souran (Japan) | |
| Shining Force Feather (Japan) | |
| Shining Stars - Super Starcade (Europe) (En,Fr,De,Es,It) | |
| Shining Stars - Super Starcade (USA) | |
| Shinreigari - Ghost Hound DS (Japan) | |
| Shinri Kenkyuuka Yuki Yu Kanshuu - Mainichi Kokorobics - DS Therapy (Japan) | |
| Shinseiki Evangeli | |
| on - Ayanami Ikusei Keikaku DS with Asuka Hokan Keikaku (Japan) | |
| Shion no Ou - The Flowers of Hard Blood (Japan) | |
| Shiseido Beauty Solution Kaihatsu Center Kanshuu - Project Beauty (Japan) | |
| Shoho kara Hajimeru - Otona no Eitango Renshuu (Japan) | |
| Shokugyou Taiken Adventure - 13-sai no Hello Work DS (Japan) | |
| Shorts (USA) (En,Fr) | |
| Shougi World Champion - Gekisashi DS (Japan) | |
| Shounen Kininden Tsumuji (Japan) | |
| Shounen Sunday & Shounen Magazine - White Comic (Japan) | |
| Showtime Championship Boxing (Europe) (En,Fr,De,Es,It) | |
| Showtime Championship Boxing (USA) | |