| Up (USA) (En,Fr) | |
| Uranai Demo Shite Miyouka DS (Japan) | |
| Urbz, The - Sims in the City (Europe) (En,Fr,De,Es,It) | |
| Urbz, The - Sims in the City (Japan) | |
| Urbz, The - Sims in the City (USA) | |
| Urusei Yatsura - Endless Summer (Japan) | |
| USA Today Crossword Challenge (USA) (En,Es) | |
| USA Today Puzzle Craze (USA) | |
| Utacchi (Japan) | |
| Utsukushii Nihongo no Kakikata Hanashikata DS (Japan) | |
| Utsukushiku Narou - Duke Saraie no Kenkou Walking Navi (Japan) | |
| Uwasa no Midori-kun!! - Natsuiro Striker (Japan) | |
| Uwasa no Midori-kun!! 2 - Futari no Midori! (Japan) | |
| V8 Supercars Australia 3 - Create & Race (Australia) (En,Fr,De,Es,It) | |
| Valentines Day (Europe) | |
| Valkyrie Profile - Covenant of the Plume (Europe) | |
| Valkyrie Profile - Covenant of the Plume (USA) | |
| Valkyrie Profile - Toga o Seou Mono (Japan) | |
| Vampire Knight DS (Japan) | |
| Vampire Legends - Power of Three (USA) (NDSi Enhanced) | |
| Vampire Moon - The Mystery of the Hidden Sun (Europe) (En,Fr,De,Es,It,Nl) | |
| Vampire Moon - The Mystery of the Hidden Sun (USA) (En,Fr,Es) | |
| Vecinos Invasores (Spain) | |
| Vegas Casino (USA) | |
| Vegas Casino High 5! (Europe) (En,Fr,De,Es,It) | |
| Veronica Poker (Netherlands) | |
| Vie d'Emma, La - Infirmiere de Choc (France) | |
| Vie d'Emma, La - Super Star (Europe) (En,Fr,It) | |
| Viewtiful Joe - Double Trouble! (Europe) | |
| Viewtiful Joe - Double Trouble! (France) | |
| Viewtiful Joe - Double Trouble! (Germany) | |
| Viewtiful Joe - Double Trouble! (Italy) | |
| Viewtiful Joe - Double Trouble! (Spain) | |
| Viewtiful Joe - Double Trouble! (USA) | |
| Viewtiful Joe - Scratch! (Japan) | |
| Virtual Villagers - A New Home (USA) (En,Fr,Es) | |
| Virtual Villagers - Erschaffe dein Paradies! (Europe) (En,Fr,De,Es,It) | |
| Visual Logic Training (Europe) (En,Fr,De,Es,It) | |
| Vita di Emma, La - Professione Infermiera (Italy) (Fr,It) | |
| VitaminX Evolution - Super Supplement Boys Goes On (Japan) | |
| VitaminY - Super Supplement Minigames with B6 & T6 (Japan) | |
| Viva Pinata - Pocket Paradise (USA) (En,Fr,Es) | |
| Voca Mania - Ameliore Ton Vocabulaire en T'Amusant! (France) | |
| Vorschulspass mit Benjamin Bluemchen (Germany) | |
| Wacky Races - Crash & Dash (Europe) (En,Fr,De,Es,It) | |
| Wacky Races - Crash & Dash (USA) (En,Fr,De,Es,It) | |
| Wagamama Fashion - Girls Mode (Japan) | |
| Wakabayashi Fumie no DS Kabu Lesson (Japan) | |
| Waku Waku DS 1 Nensei (Japan) | |
| Walk with Me! (Europe) (En,Fr,De,Es,It) (Rev 1) | |