| Scotland Yard - Hunting Mister X (Europe) (En,De) | |
| Scrabble - Crossword Game (USA) | |
| Scrabble Interactive - 2007 Edition (Europe) (En,Fr) | |
| Scrabble Interactive - 2009 Edition (Europe) (En,Fr) | |
| Scribblenauts (Europe) (En,Fr,De,Es,It,Nl) | |
| Scribblenauts (Europe) (En,Sv,No,Da,Fi) | |
| Scribblenauts (USA) (En,Fr,Es,Pt) | |
| Scurge - Hive (Europe) (En,Fr,De,Es,It) | |
| Scurge - Hive (USA) (En,Fr,Es) | |
| SD Gundam G Generation - Cross Drive (Japan) | |
| SD Gundam G Generation DS (Japan) | |
| SD Gundam Sangoku Den - Brave Battle Warriors - Shin Militia Taisen (Japan) | |
| Sea Monsters - A Prehistoric Adventure (Europe) (En,Fr,De,Es,It) | |
| Sea Monsters - A Prehistoric Adventure (USA) | |
| Sea Park Tycoon (Europe) (En,Fr, | |
| De,Es,It,Nl,Sv,No,Da,Fi) | |
| Sea Park Tycoon (USA) | |
| Secret Files - Tunguska (Europe) (En,Fr,De,Es,It) | |
| Secret Files - Tunguska (USA) (En,Fr,De,Es,It) | |
| Secret Files 2 - Puritas Cordis (Europe) (En,Fr,De,Es,It) | |
| Secret Flirts - Make Everyone Fall For You! (Europe) (En,Fr,De,Es,It,Nl) | |
| Secret Saturdays, The - Beasts of the 5th Sun (Europe) (En,Fr,De,Es,It) | |
| Secret Saturdays, The - Beasts of the 5th Sun (USA) (En,Fr,Es) | |
| Secret Story - Le Jeu Officiel de l'Emission (France) | |
| Sega Casino (Europe) (En,Fr,De,Es,It) | |
| Sega Casino (USA) (En,Fr,De,Es,It) | |
| Sega Presents - Touch Darts (Europe) | |
| Sega Superstars Tennis (Europe) (En,Fr,De,Es,It) | |
| Sega Superstars Tennis (USA) (En,Fr,De,Es,It) | |
| Seiken Densetsu - Heroes of Mana (Japan) | |
| Seiken Densetsu DS - Children of Mana (Japan) | |
| Seitokai no Ichizon - DS Suru Seitokai (Japan) | |
| Sekai Fushigi Hakken! DS - Densetsu no Hitoshi-kun Ningyou o Sagase! (Japan) | |
| Sekai no Gohan - Shaberu! DS Oryouri Navi (Japan) | |
| Sekai no Hate made ItteQ! - Chinjuu Hunter Imoto no Daibouken (Japan) | |
| Sekai no Shougi (Japan) | |
| Sekai wa Atashi de Mawatteru (Japan) | |
| Sekaiju no Meikyuu (Japan) | |
| Sekaiju no Meikyuu II - Shoou no Seihai (Japan) | |
| Sekaiju no Meikyuu III - Seikai no Raihousha (Japan) | |
| Sekaishi DS (Japan) | |
| Sengoku Spirits - Gunshi Den (Japan) | |
| Sengoku Spirits - Moushou Den (Japan) | |
| Sengoku Spirits - Shukun Den (Japan) | |
| Settlers, The (Europe) (En,Fr,De,Es,It) | |
| Settlers, The (Europe) (En,Fr,De,Es,It) (Rev 1) | |
| Settlers, The (USA) (En,Fr,De,Es,It) | |
| Shaberu! DS Oryouri Navi - Marugoto Teikoku Hotel (Japan) | |
| Shaberu! DS Oryouri Navi (Japan) | |
| Shaberu! DS Oryouri Navi (Japan) (Rev 1) | |
| Shakugan no Shana DS (Japan) | |