| E=M6 Defi Cerebral (France) | |
| EA Playground (Europe) (En,Fr,De,Es,It) | |
| EA Playground (Korea) | |
| EA Playground (USA) (En,Fr,De,Es,It) | |
| Easy Learning - Discover Our World (Europe) (En,Fr,De,Es,It) | |
| Easy Piano - Learn, Play & Compose (Europe) (En,Fr,De,Es,It) | |
| Easy Piano (USA) (En,Fr,Es) | |
| Eco-Creatures - Save the Forest (USA) | |
| Ecolis - Aoi Umi to Ugoku Shima (Japan) | |
| Ecolis - Save the Forest (Europe) (En,Fr,De,Es,It) | |
| Ecolis (Japan) | |
| Ed, Edd n Eddy - Scam of the Century (Europe) (En,Fr,De,Es,It) | |
| Ed, Edd n Eddy - Scam of the Century (USA) | |
| Ed's Farm (Europe) (En,Fr,De,Es,It) | |
| Edamoto Naomi no Shiawase Kitchen - Kakushi Aji wa Anata ga Kimete ne (Japan) | |
| Edo Bunka Rekishi Kentei DS (Japan) | |
| Edogawa Ranpo no Kaijin Nijuu Mensou DS (Japan) | |
| Egg Monster Hero (Japan) | |
| Egokoro Kyoushitsu DS (Japan) (NDSi Enhanced) | |
| Eibun Tadoku DS - Sekai no Bungaku Senshuu (Japan) | |
| Eibun Tadoku DS - Sekai no Meisaku Douwa (Japan) | |
| Eigo de Tabisuru - Little Charo (Japan) | |
| Eigo ga Nigate na Otona no DS Training - Eigo Zuke (Japan) | |
| Eigo ga Nigate na Otona no DS Training - Eigo Zuke (Japan) (Rev 1) | |
| Eigo ga Nigate na Otona no DS Training - Motto Eigo Zuke (Japan) | |
| Eigo o Taberu Fushigi na Ikimono - Marsh (Japan) | |
| Eigyoudou, The (Japan) | |
| Eijukugo Target 1000 DS (Japan) | |
| Eiken DS (Japan) | |
| Eiken DS Training (Japan) | |
| Eiken Kakomondai Shuuroku - Eiken DS 2 Deluxe (Japan) | |
| Eiken-ou - 2-kyuu Hen (Japan) | |
| Eiken-ou - 3-kyuu Hen (Japan) | |
| E | |
| iken-ou - 4-kyuu Hen (Japan) | |
| Eiken-ou - Jun-2-kyuu Hen (Japan) | |
| Eikoh Seminar Koushiki DS Kyouzai - Chuugaku Eitango - Eitan Zamurai DS (Japan) | |
| Eikoh Seminar Koushiki DS Kyouzai - Koukou Eitango - Eitan Zamurai DS (Japan) | |
| Eikoh Seminar Koushiki DS Kyouzai - Shougakkou Eitango - Eitan Zamurai DS (Japan) | |
| Eindeloos Backgammon (Netherlands) | |
| Eindeloos Games Top 10 (Netherlands) | |
| Eindeloos Mahjong (Netherlands) (En,Nl) | |
| Eindeloos Mahjong 2 - Een Reis om de Wereld (Netherlands) | |
| Eindeloos Patience (Netherlands) | |
| Eitango Target 1900 DS (Japan) | |
| Eiyuu Senki - Laevatein (Japan) | |
| Elebits - Kai to Zero no Fushigi na Tabi (Japan) | |
| Elebits - Kaiwa Zeroui Sinbihan Yeohaeng (Korea) | |
| Elebits - The Adventures of Kai and Zero (USA) (En,Fr) | |
| Electroplankton (Europe) (En,Fr,De,Es,It) | |
| Electroplankton (Japan) | |