| Sega Superstars Tennis (Europe) (En,Fr,De,Es,It) | |
| Sega Superstars Tennis (USA) (En,Fr,De,Es,It) | |
| Seiken Densetsu - Heroes of Mana (Japan) | |
| Seiken Densetsu DS - Children of Mana (Japan) | |
| Seitokai no Ichizon - DS Suru Seitokai (Japan) | |
| Sekai Fushigi Hakken! DS - Densetsu no Hitoshi-kun Ningyou o Sagase! (Japan) | |
| Sekai no Gohan - Shaberu! DS Oryouri Navi (Japan) | |
| Sekai no Hate made ItteQ! - Chinjuu Hunter Imoto no Daibouken (Japan) | |
| Sekai no Shougi (Japan) | |
| Sekai wa Atashi de Mawatteru (Japan) | |
| Sekaiju no Meikyuu (Japan) | |
| Sekaiju no Meikyuu II - Shoou no Seihai (Japan) | |
| Sekaiju no Meikyuu III - Seikai no Raihousha (Japan) | |
| Sekaishi DS (Japan) | |
| Sengoku Spirits - Gunshi Den (Japan) | |
| Sengoku Spirits - Moushou Den (Japan) | |
| Sengoku Spirits - Shukun Den (Japan) | |
| Settlers, The (Europe) (En,Fr,De,Es,It) | |
| Settlers, The (Europe) (En,Fr,De,Es,It) (Rev | |
| 1) | |
| Settlers, The (USA) (En,Fr,De,Es,It) | |
| Shaberu! DS Oryouri Navi - Marugoto Teikoku Hotel (Japan) | |
| Shaberu! DS Oryouri Navi (Japan) | |
| Shaberu! DS Oryouri Navi (Japan) (Rev 1) | |
| Shakugan no Shana DS (Japan) | |
| Shamu's Deep Sea Adventures (Europe) | |
| Shamu's Deep Sea Adventures (USA) | |
| Shane Watson's Power Play Cricket 2011 (Australia) | |
| Shanghai (Japan) | |
| Shaun the Sheep - Off His Head (Europe) (En,Fr,De,Es,It) | |
| Shaun the Sheep (Europe) (En,Ja,Fr,De,Es,It) | |
| Shaun the Sheep (USA) (En,Ja,Fr,De,Es,It) | |
| Shaun White Snowboarding (Europe) (En,Fr,De,Es,It) | |
| Shaun White Snowboarding (USA) (En,Fr,Es) | |
| Shawn Johnson Gymnastics (USA) (En,Fr,Es) | |
| Shepherd's Crossing 2 DS (USA) | |
| Sherlock Holmes - The Mystery of the Mummy (USA) (En,Fr,Es) | |
| Sherlock Holmes DS - The Mystery of the Mummy (Europe) (En,Fr,De,Es,It) | |
| Sherlock Holmes DS and the Mystery of Osborne House (Europe) (En,Fr,De,Es,It,Nl) | |
| Shibou Nenshou Keikaku - Yasetore!! DS (Japan) | |
| Shichida Shiki Training - Unou Tanren Unotan DS - Shun Kan Shoubu! Handanryoku (Japan) | |
| Shichida Shiki Training - Unou Tanren Unotan DS - Shun Kan Shoubu! Kiokuryoku (Japan) | |
| Shichida Shiki Training - Unou Tanren Unotan DS - Shun Kan Shoubu! Shuuchuuryoku (Japan) | |
| Shichidasik Unoedallyeon - Super Brain (Korea) | |
| Shikaku Kentei DS (Japan) | |
| Shikakui Atama o Maruku Suru. DS - Joushiki, Nanmon no Shou (Japan) | |
| Shikakui Atama o Maruku Suru. DS - Kanji no Shou (Japan) | |
| Shikakui Atama o Maruku Suru. DS - Keisan no Shou (Japan) | |
| Shin chan - Aventuras de Cine! (Spain) | |
| Shin chan contra los Plastas! (Spain) | |
| Shin chan e i Colori Magici! (Italy) | |