| Super Robot Taisen K (Japan) | |
| Super Robot Taisen L (Japan) | |
| Super Robot Taisen OG Saga - Endless Frontier (USA) | |
| Super Robot Taisen OG Saga - Masou Kishin - The Lord of Elemental (Japan) | |
| Super Robot Taisen W (Japan) | |
| Super Scribblenauts (Europe) (En,Fr,De,Es,It,Nl) | |
| Super Scribblenauts (USA) (En,Fr,Es,Pt) | |
| Super Speed Machines (USA) | |
| Super Star Kartz (USA) (En,Fr) | |
| Superman Returns (Europe) (En,Fr,De,Es,It) | |
| Superman Returns (USA) | |
| Supermodel Makeover by Lauren Luke (Europe) (En,Fr,De,It) | |
| Supervivientes (Spain) | |
| Surf's Up (Europe) (En,Fr,De,Es,It) | |
| Surf's Up (Europe) (En,Fr,Es) | |
| Surf's Up (USA) (En,Fr,Es) | |
| Survival Kids - Chiisana Shima no Ookina Himitsu! (Japan) | |
| Survival Kids - Lost in Blue (Japan) | |
| Survival Kids - Lost in Blue 2 (Japan) | |
| Sushi Academy (Europe) (En,Fr,De,Es,It) | |
| Sushi Academy (USA) (En,Fr,Es) | |
| Sushi Go-Round (USA) (En,Fr,De,Es,It) (NDSi Enhanced) | |
| Suugaku Master DS (Japan) | |
| Suujin Taisen (Japan) | |
| Suzuki Super-Bikes II - Riding Challenge (USA) | |
| Suzumiya Haruhi no Chokuretsu (Japan) | |
| Sweet 16 (Europe) (En,Fr,De,Es,It) | |
| Syberia (Europe) (En,Fr,De,Es,It) | |