| Sabrina - The Animated Series - Spooked! (USA) | |
| Sabrina - The Animated Series - Zapped! (Europe) (En,Fr,De) | |
| Sabrina - The Animated Series - Zapped! (USA, Europe) | |
| Sakata Gorou Kudan no Renju Kyoushitsu (Japan) | |
| Sakura Taisen GB - Geki Hana Kumi Nyuutai! (Japan) | |
| Sakura Taisen GB2 - Thunderbolt Sakusen (Japan) | |
| Samurai Kid (Japan) | |
| San Francisco Rush 2049 (USA) | |
| Sangokushi - Game Boy Ban 2 (Japan) | |
| Sanrio Timenet - Kako Hen (Japan) | |
| Sanrio Timenet - Mirai Hen (Japan) | |
| Santa Claus Junior (Europe) | |
| Saru Puncher (Japan) | |
| Scooby-Doo! - Classic Creep Capers (USA, Europe) | |
| Scrabble (Europe) | |
| SD Hiryuu no Ken EX (Japan) | |
| Sei Hai Densetsu (Japan) | |
| Seme COM Dungeon - Drururuaga (Japan) | |
| Senkai Ibunroku Juntei Taisen - TV Animation Senkaiden Houshin Engi Yori (Japan) | |
| Sesame Street Sports (USA) | |
| Sgt. Rock - On the Frontline (USA) | |
| Shadowgate Classic (USA, Europe) (En,Fr,De,Es,Sv) | |
| Shadowgate Classic (USA, Europe) (En,Fr,De,Es,Sv) (Rev A) | |
| Shadowgate Return (Japan) | |
| Shaman King Card Game - Chou Senjiryakketsu - Funbari Hen (Japan) | |
| Shaman King Card Game - Chou Senjiryakketsu - Meramera Hen (Japan) | |
| Shamus (USA) | |
| Shanghai Pocket (USA, Europe) (Rev A) | |
| Shanghai Pocket (USA) | |
| Shantae (USA) | |
| Shaun Palmer's Pro Snowboarder (USA) | |
| Shin Megami Tensei Devil Children - Aka no Sho (Japan) | |
| Shin Megami Tensei Devil Children - Kuro no Sho (Japan) | |
| Shin Megami Tensei Devil Children - Shiro no Sho (Japan) | |
| Shin Megami Tensei Trading Card - Card Summoner (Japan) | |
| Shinseiki Evangelion - Mahjo | |
| ng Hokan Keikaku (Japan) | |
| Shougi 2 (Japan) | |
| Shougi 3 (Japan) | |
| Shrek - Fairy Tale Freakdown (USA) (En,Fr,De,Es,It) | |
| Shuma Baobei - Chao Mengmeng Fanji Zhan (Unlicensed, Chinese) | |
| Shuma Baobei - Hai Zhi Shen (Unlicensed, Chinese) | |
| Shuma Baobei - Huojian Bingtuan (Unlicensed, Chinese) | |
| Shutokou Racing, The (Japan) | |
| Simpsons, The - Night of the Living Treehouse of Horror (USA, Europe) | |
| Smurfs Nightmare, The (Europe) (En,Fr,De,Es) | |
| Smurfs Nightmare, The (USA) | |
| Snobo Champion (Japan) | |
| Snoopy Tennis (Europe) (En,Fr,De,Es,It,Nl) | |
| Snoopy Tennis (Japan) | |
| Snoopy Tennis (USA) (En,Fr,Es) | |