| South Park (Germany) | |
| South Park (USA) | |
| South Park Rally (Europe) | |
| South Park Rally (USA) | |
| Space Dynamites (Japan) | |
| Space Invaders (USA) | |
| SpaceStation Silicon Valley (Europe) (En,Fr,De,Es,It,Nl,Pt) | |
| SpaceStation Silicon Valley (Japan) (Proto) | |
| SpaceStation Silicon Valley (USA) | |
| Speed Star Adventure | |
| Spider-Man (USA) | |
| Spider-Man in Smash Rem | |
| ix 1.5.0 | |
| Squash 64 | |
| Star Fox 64 (Japan) | |
| Star Fox 64 (USA) | |
| Star Fox 64 (USA) (Rev A) | |
| Star Fox 64 Randomizer Beta.40 | |
| Star Fox 64: Survival | |
| Star Soldier - Vanishing Earth (Japan) | |
| Star Soldier - Vanishing Earth (USA) | |
| Star Twins (Japan) | |
| Star Wars - Rogue Squadron (Europe) (En,Fr,De) | |
| Star Wars - Rogue Squadron (Europe) (En,Fr,De) (Rev A) | |
| Star Wars - Rogue Squadron (USA) | |
| Star Wars - Rogue Squadron (USA) (Rev A) | |
| Star Wars - Shadows of the Empire (Europe) | |
| Star Wars - Shadows of the Empire (USA) | |
| Star Wars - Shadows of the Empire (USA) (Rev A) | |
| Star Wars - Shadows of the Empire (USA) (Rev B) | |
| Star Wars - Shutsugeki! Rogue Chuutai (Japan) | |
| Star Wars - Teikoku no Kage (Japan) | |
| Star Wars Episode I - Battle for Naboo (Europe) | |
| Star Wars Episode I - Battle for Naboo (USA) | |
| Star Wars Episode I - Racer (Europe) (En,Fr,De) | |
| Star Wars Episode I - Racer (Japan) | |
| Star Wars Episode I - Racer (USA) | |
| StarCraft 64 (Australia) | |
| StarCraft 64 (Germany) (Proto) | |
| StarCraft 64 (USA) | |
| Starline The Platypus 64 | |
| Starshot - Space Circus Fever (Europe) (En,Fr,De) | |
| Starshot - Space Circus Fever (USA) (En,Fr,Es) | |
| Strange Fruits - Melon | |
| Stunt Racer 64 (USA) | |
| Super B-Daman - Battle Phoenix 64 (Japan) | |
| Super Beatrice 64 | |
| Super Bowling (Japan) | |
| Super Bowling (USA) | |
| Super Bowser 64 | |
| Super Bowsette 64 By Kaze Emanuar | |