| Section Z (set 2) | |
| Sector Zone | |
| Sega Ninja (315-5102) | |
| Sega Ninja (not encrypted) | |
| Sega Rally Championship - Twin/DX (Revision C) | |
| SegaSonic Bros. (prototype, hack) | |
| SegaSonic Cosmo Fighter (World) | |
| SegaSonic Popcorn Shop (Rev B) | |
| SegaSonic The Hedgehog (Japan, prototype) | |
| SegaSonic The Hedgehog (Japan, rev. C) | |
| Sei Senshi Amatelass | |
| Seicross | |
| Seishun Scandal (315-5132, Japan) | |
| Sel Feena | |
| Sen Jing - Guardian Storm (Japan) | |
| Sen-Know (Japan) | |
| Sengeki Striker (Asia) | |
| Sengeki Striker (Japan) | |
| Sengoku / Sengoku Denshou (NGH-017)(US) | |
| Sengoku / Sengoku Denshou (NGM-017)(NGH-017) | |
| Sengoku 2 / Sengoku Denshou 2 | |
| Sengoku 3 / Sengoku Densho 2001 | |
| Sengoku 3 / Sengoku Densho 2001 (Evolution 1.0, FCHT hack) [Hack] | |
| Sengoku Ace (Japan, set 2) | |
| Sengoku Ace (Japan) | |
| Senjo no Ookami II (Ookami 2 900302 Japan) | |
| Senjou no Ookami | |
| Sexy Parodius (ver JAA) | |
| SF-X [Incomplet | |
| e Sound] | |
| Shackled (US) | |
| Shadow Dancer (set 1) | |
| Shadow Dancer (set 2, Japan) | |
| Shadow Dancer (set 3, US) | |
| Shadow Force (Japan Version 2) | |
| Shadow Force (Japan Version 3) | |
| Shadow Force (US, Version 2) | |
| Shadow Force (World, Version 3) | |
| Shadow Warriors (World, set 1) | |
| Shadow Warriors (World, set 2) | |
| Shadowland (YD3) | |
| Shao-lin's Road (set 1) | |
| Shao-lin's Road (set 2) | |
| Sheriff | |
| Shingen Samurai-Fighter (Japan, English) [Game crashes in level 2, play tshingena instead!] | |
| Shinnyuushain Tooru-kun | |
| Shinobi (beta bootleg, System 16A) [Bootleg] | |
| Shinobi (set 1, System 16A, FD1094 317-0050 decrypted) [Bootleg] | |
| Shinobi (set 1, System 16A, FD1094 317-0050) | |
| Shinobi (set 2, System 16B, FD1094 317-0049 decrypted) [Bootleg] | |
| Shinobi (set 2, System 16B, FD1094 317-0049) | |